ACS Nano, 2011, 5, 3146.

18F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly

Qian Liu†, Yun Sun†, Chenguang Li†, Jing Zhou†, Chunyan Li†, Tianshe Yang†, Xianzhong Zhang‡, Tao Yi†*, Dongmei Wu§, and Fuyou Li†*
Joint Center of Biomedical Imaging (BMI) of Department of Chemistry & Institute of Biomedical Science & Cancer Hospital, and Advanced Materials Laboratory, Fudan University, 200433, People’s Republic of China
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, People’s Republic of China
§ Shanghai Key Laboratory of Magnetic Resonance, Physics Department, East China Normal University, Shanghai 200062, People’s Republic of China
ACS Nano, 2011, 5 (4), pp 3146–3157
DOI: 10.1021/nn200298y
Publication Date (Web): March 8, 2011

A novel method of rare-earth cation-assisted ligand assembly has been developed to provide upconversion nanophosphors with T1-enhanced magnetic resonance (MR), radioactivity, and targeted recognition properties, making these nanoparticles potential candidates for multimodal bioimaging. The process of modifying the surface of the nanophosphors has been confirmed by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, energy-dispersive X-ray analysis, and so on. The versatility of this surface modification approach for incorporating functional molecules and fabricating fluorine-18-labeled magnetic-upconversion nanophosphors as multimodal bioprobes has been demonstrated by targeted cell imaging, in vivo upconversion luminescence, MR imaging, and positron emission tomography imaging of whole-body small animals.