Scientists have identified a chemical that can grow new neurons. It works, is assigned primarily to one part of the brain, learning and memory.
The discovery could lead, after researchers in a systematic and carefully checked every 1,000 different chemicals in the brain of living mice was the issue of the journal Cell, the way a novel neuroprotective for people with Alzheimer’s disease and other neurodegenerative diseases, drugs, according to a report in the press release of 9 July.
“I do not know if a link-view will remove favorable or not,” said Steven McKnight of the University of Texas Southwestern. “It was a matter of luck.”
“Our chances slim,” added Andrew Pieper, UT Southwestern. “But we knew from the moment that we found something that has already been signed, that this has worked in animal welfare.” Promising candidates in all cell cultures led does not work often.
McKnight and Pieper was the proof, which also, that the mammalian brain adding new nerve cells to excite in adulthood. The question was whether you have a chance, these cells could develop as beneficial for the promotion.
Early-stage drug candidates in the screen eight rats by researchers, establishing a functioning neurons (called the dentate gyrus) known to support new nerve cells in the adult cabbage, was published. These chemical properties of eight candidates in one attention P7C3 name based on other cheap medicines.
To find out how well you can run the P7C3, researchers can test it in mice with the mutation, the power of the dentate gyrus of new nerve cells in almost completely incapable of a critical region of code.
“.” These rats are bad creation of new nerve cells, said McKnight, “The question was correct and the answer is” yes. ” ”
Not only is the new type of neuron, but electrophysiological derivatives also showed that the processing of the dentate gyrus of the brain was given. “Do it right, like enough, that we really had shown that new nerve cells to work,” said McKnight.
Improve in a larger treatment of old mice with P7C3 the birth of new neurons. “At the age of rats usually show a decrease in neurogenesis with disabilities, new memories and vocational learning, doing,” says Pieper.
The key to the success of treatment is reported to protect newborn neurons, researchers. In fact, that said the normal procedure, as newborn neurons in the brain cells embedded tires, is a long and dangerous.
“Takes two minutes long – before – four weeks after the birth of a new neuron until it’s OK,” said McKnight. “Most of them died on the way.” Newborn neurons seems likely essentially P7C3.
It is worth noting that two other drugs (GE and welding connections Serono) – also the two structural similarities with P7C3, sharp growth promoting new nerve cells. It is tempting to believe that the three links work the same way.
In fact, the GE series came first, the attention of researchers in Russian medical reports that the symptoms of age-related cognitive abilities drug may improve in the command. Unfortunately, no published reports of a Phase 3 trial were guilty of the drug can solve the memory loss that accompanies the offer of proof remained acetylgalactosaminidase.
In the light of new information, the value may differ. “Idea of speculation that these chemicals are a common mode of action only share strictly in accordance with the determination of the molecular target (s) under test.” The molecular target is an activation ID P7C3 pages researcher to the next question.